Covid booster jabs extended to 40-49 age group and second doses for 16 to 17 year olds

The Covid vaccine booster programme is being extended to include healthy 40 to 49-year-olds, it has been confirmed this morning.

Health officials are also advising that all 16 to 17-year-olds should be offered a second jab.

The Joint Committee on Vaccination and Immunisation (JCVI) has advised that all adults aged 40 to 49 years should be offered a booster, 6 months after their second dose, irrespective of the vaccines given for the first and second doses.

The JCVI says that “recent UK and international data have provided early signs of a slight fall in the levels of protection against severe disease from the primary doses, in those who had their initial vaccines a long time ago.”

Booster vaccines are being offered to eligible groups to help them maintain high levels of protection against hospitalisation, severe illness or dying over the winter.

The vast majority of the UK adult population has received a COVID-19 vaccine since the programme was launched in December 2020 – including 87.9% of the population who have received a first dose and 80% who have received 2 doses.

JCVI has previously advised booster vaccination for all adults aged 50 years and over and those in a COVID-19 at-risk group.

The offer has now been broadened to include those aged 40 to 49 years.

“Booster vaccination should be with either the Pfizer-BioNTech vaccine, or the Moderna vaccine, as previously advised.”

“Both of these vaccines are expected to give a good level of extra protection.”

The advice comes as the UK Health Security Agency (UKHSA) publishes the first data on booster vaccine effectiveness in the UK.

The analysis shows that people who take up the offer of a booster vaccine increase their protection against symptomatic COVID-19 infection to over 90%.

Protection against more severe disease is expected to be even higher.

Following 2 doses of the vaccine – as yet – there is no robust evidence of a decline in protection against severe COVID-19 (hospitalisation and deaths) in those aged under 40.

JCVI says it will continue to closely review all available data to develop further advice in due course.

The JCVI is also advising that all 16 to 17 year olds who are not in an at-risk group should be offered a second dose of the Pfizer vaccine. The second vaccine dose should be given 12 weeks or more following the first vaccine dose.

For those in this age group who have had COVID-19 infection, the second vaccine dose should be given 12 weeks or more following the first vaccine dose, or 12 weeks following a positive COVID-19 test result – whichever is later.

This advice is in addition to the existing offer of 2 doses of vaccine to 16 to 17 year olds who are in ‘at-risk’ groups.

The decision to advise the second dose is based on a review of the latest evidence of the benefits of the vaccine programme, compared to the risks of any side effects.

JCVI says that “a second vaccine dose increases the level of protection and is important for extending the duration of protection.”

“As protection from the first dose will eventually start to decline, the benefits from the second vaccine dose will become more important over time.”

“A second dose may also offer a reduction in the risk of hospitalisation and onward transmission to vulnerable close contacts.”

In reports originating from outside the UK, extremely rare adverse reactions, such as myocarditis (inflammation of the heart) have been reported more frequently after the second vaccine dose compared to the first vaccine dose.

However, in countries such as Canada and the UK, who have a longer interval between the first and second doses, rates following the second vaccine dose are closer to the reporting rate after the first dose.

“The latest available data indicate that myocarditis following vaccination usually resolves within a short time, most cases respond well to treatment and where information is available, no major complications have been identified in the medium term (months).” JCVI says.

“Taking these factors into consideration, JCVI has concluded that the balance of risks and benefits supports offering a second dose of the Pfizer-BioNTech COVID-19 vaccine in persons aged 16 to 17 years who are not in an at-risk group.” It adds.

Professor Wei Shen Lim, Chair, COVID-19 immunisation, JCVI said:

“Booster vaccine doses in more vulnerable adults, and second vaccine doses in 16 to 17 year olds are important ways to increase our protection against COVID-19 infection and severe disease.”

“These vaccinations will also help extend our protection into 2022.”

MHRA Chief Executive, Dr June Raine said:

“We welcome today’s announcement by the JCVI, on the extension of the booster campaign to 40-49 year olds. This further strengthens our ability to ensure people are protected against COVID-19 and saves lives.”

“Our safety monitoring to date shows that COVID-19 vaccines continue to have a positive safety profile for the majority of people.”

“The vast majority of reactions which are reported relate to expected side effects such as injection site reactions and flu-like symptoms, as was seen in our initial assessment. Our proactive monitoring of the safety of booster doses does not raise any new concerns.”

“We also welcome the recommendation for 16-17 year-olds to come forward and have a second dose of the Pfizer/BioNTech vaccine.”

“People can be reassured that when we gave approval for the Pfizer vaccine for those 16 years and over in December 2020, we had thoroughly reviewed all the clinical trial data.”

“We have continued to carefully scrutinise all the data we have available to us and our robust surveillance programme includes monitoring all suspected reactions for adolescents as well as adults.”

“We ensure all suspected reports are carefully followed up. The Expert Working Group of the Commission on Human Medicines has confirmed that reports of suspected myocarditis (heart inflammation) following COVID-19 vaccines are extremely rare and that the balance of risks and benefits overall remains favourable.”